Genetic engineering based on CRISPR

Genetic Engineering based on CRISPR: We employ high-throughput screening to identify strains with the fastest growth rates and use Al-assisted metabolic flux analysis for genetic modification, enhancing strain productivity.

Genetic engineering based on CRISPR
Advanced Technology

Directed evolution for microorganisms

We isolate microorganisms from natural environments that meet our requirements and subsequently apply directed evolution techniques to impose selective pressures, thereby optimizing strains for maximum yield and efficient waste degradation.

Directed evolution for microorganisms

Precise fermentation for mass production

Our precise fermentation system cultures engineered microorganisms to produce bio-based raw materials. In a nearly 100-ton fermentation setup, we implement real-time monitoring and precise control of parameters such as temperature, pH, and dissolved oxygen to ensure optimal biomaterial synthesis.

Precise fermentation for mass production

Algae carbon-negative technology

We utilize microalgae systems to treat fermented wastewater. Microalgae absorb small organic molecules from the wastewater, converting them into nutrients while capturing atmospheric CO2 during photosynthesis. The post-fermentation nutrient-rich biomass is then formulated into liquid fertilizer for agricultural application.


Algae carbon-negative technology

Material characteristic modification technology

Tailoring bio-materials to downstream applications. we modity their physical properties-such as softness, skin compatibility. and elasticity-through advanced processing techniques.

Material characteristic modification technology

Precision coating processing

Bio-based leather can be constructed from five distinct layers of material, each featuring its own unique formulation. During processing, we employ patented coating techniques to precisely control the thickness of each layer, thereby enabling bio-based leather to achieve tailored surface texture, physical properties, and tactile experience across different application scenarios.

Precision coating processing
Process
Strain optimization
01
Strain optimization
Gene editing is performed on the specific metabolic pathways of the strain for producing biomaterials. The efficiency of the strain in producing biomaterials is enhanced by knocking out key enzymes that interfere with the pathway or introducing gene parts that enhance the expression of metabolic pathway genes.
Biomaterial fermentation
02
Biomaterial fermentation
Under artificially controlled conditions, the optimized strains degrade and transform energy substances through their own metabolic activities, and finally synthesize biomaterials such as mycelium and biopolymer polyester elastomers.
Purification of biomaterials
03
Purification of biomaterials
Through centrifugation, filtration, breaking, washing and other methods, the excess cells and other metabolites in the fermentation broth are removed to extract the biological materials.
Microalgae processing<br> and biomaterial synthesis
04
Microalgae processing
and biomaterial synthesis
Microalgae can grow and reproduce in the presence of light sources, using carbon dioxide, amino acids and other substances as carbon sources and energy sources. The fermentation residue separated after purification is introduced into the microalgae culture system. The various metabolites in the fermentation residue and the carbon dioxide produced during the production process provide energy for the growth and reproductor of microalgae. At the same time, microalgae can also purify the fermentation residue. The purified liquid can be used as a nutrient fertilizer. The microalgae in the culture
Leather slurry compounding
05
Leather slurry compounding
The purified biomass raw materials are dried and crushed into powder, which are then compounded with other materials to form leather slurries with different functions. Artificial leather mainly consists of five layers: surface treatment agent layer, dense layer, foaming layer, adhesive laver and base fabric laver. Different bio-based leather slurries are prepared according to the performance differences of different layers.
Leather processing
06
Leather processing
SynMetabio's leather production and processing is mainly adapted to the dry coating process. The prepared slurry is scraped onto the release paper in the order of dense layer, foaming layer, and adhesive layer. and then dried. After drying, the next layer of slurry is applied. The overall thickness of the surface elastomer is controlled by controlling the gap between the scraper and the release paper.
100% Bio-Based Content Certification
100% Bio-Based Content Certification

Synmetabio has received USDA Certified Biobased status with 100% bio-based content, verified by Beta Laboratories.

61% Bio-Based Content Certification
61% Bio-Based Content Certification

Synmetabio has received USDA Certified Biobased status with 61% bio-based content, verified by Beta Laboratories.

33% Bio-Based Content Certification
33% Bio-Based Content Certification

Synmetabio has received USDA Certified Biobased status with 33% bio-based content, verified by Beta Laboratories.

Carbon Negative Certification
Carbon Negative Certification

In 2024, Synmetabio’s bio-leather was certified by SGS to ISO 14067, with a lifecycle carbon footprint of -17 kg CO₂ per kg.

Certification
100% Bio-Based Content Certification
61% Bio-Based Content Certification
33% Bio-Based Content Certification
Carbon Negative Certification
2022 International CMF Design Award
2022 International CMF Design Award

SynMetabio won the 2022 International CMF Design Award - Material Innovation Award

Award
2022 International CMF Design Award